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自1978年以来,东非恶性疟原虫对氯喹的抗性已从RI发展到RIII。本文报道了到马达加斯加旅游的两名意大利妇女感染的恶性疟对氯喹的敏感性有所降低。一例52岁,到马达加斯加前两周直到发病,曾按常规预防量(300mg/周)服用氯喹。发病时出现恶寒、高热(40℃)、出汗、头痛等症状,血栓可见疟原虫环状体4,500/μl血。开头用氯喹标准剂量治疗,但由于体外测试证明原虫对氯喹有抗性,遂用七天疗程,总剂量达2,700mg。对本例测试结果表明,完全抑制环状体发育所需的氯喹浓度为1.50nmol/小瓶,而不是
Since 1978, the resistance of Plasmodium falciparum to chloroquine in East Africa has progressed from RI to RIII. This article reports that the susceptibility of falciparum malaria to two Italian women traveling to Madagascar to reduce their susceptibility to chloroquine has been reduced. A 52-year-old to Madagascar until the onset of the first two weeks, had been taking conventional preventive doses (300mg / week) taking chloroquine. When the onset of aversion to chills, fever (40 ℃), sweating, headache and other symptoms, blood clots paralysis visible 4,500 / μl blood. Begin with chloroquine standard dose treatment, but due to in vitro tests proved protozoa resistant to chloroquine, then seven days course of treatment, the total dose of 2,700 mg. The test results for this example showed that the chloroquine concentration required to completely inhibit the development of the ring was 1.50 nmol / vial instead of