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急性肾衰(ARF)是指少尿期患者细胞外液负荷过多引起的钠和水失衡。根据在人体内注入合成的心房利钠因子(ANF)可引起迅速利钠作用,作者认为这种激素最可能作用于钠利尿的开始阶段。本文旨在测定 ARF 患者血浆 ANF 和作为第二信使的环磷鸟苷(cGMP),并观察与血肌酐(Cr)、血容量(BV)、尿钠及血浆其他激素的关系。病人和方法 12例各种原因引起的 ARF 患者,Cr≥400μmol/L,其中9例为少尿型,每日测血、
Acute renal failure (ARF) is the imbalance of sodium and water caused by extracellular fluid overload in oliguric patients. The rapid natriuretic effect is caused by the infusion of synthetic atrial natriuretic factor (ANF) into the human body and the authors suggest that the hormone most likely acts on the initial stage of natriuretic. The aim of this study was to determine plasma ANF in patients with ARF and cyclic guanosine monophosphate (cGMP) as second messenger in relation to serum creatinine (Cr), blood volume (BV), urinary sodium and other plasma hormones. Patients and methods ARF patients caused by various causes of 12 cases, Cr ≥ 400μmol / L, of which 9 cases of oliguric type, daily blood test,