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本文复习近20年来西文和日本所报告的有关胃癌手术治疗和加用辅助化疗的随访对照研究结果,辅助化疗可分成4种方案:(1)噻替哌为主的方案;(2)5氟尿嘧啶(5-FU)加或不加用甲基环亚硝脲(MeCCNU);(3)丝裂霉素加或不加用5FU;(4)以阿霉素为主的方案(如加用5FU和丝裂霉素).50年代初期.多用单一药物,如噻替哌、5-FU惑丝裂霉素.单一的5FU方案并不改善治愈性切除病例的生存率. 5-FU和MeCCNU联合就用的报告有赞同和反对的,有关意见尚不一致.由于病例选择方法不同的缘故.5- FU与长春花碱、环磷酰胺或BCNU(卡氮芥)联合应用也不见任何效益.
This article reviews the results of a follow-up study of gastric cancer surgery and adjuvant chemotherapy reported in Western and Japanese in the past 20 years. Adjuvant chemotherapy can be divided into four protocols: (1) thiotepa-based regimen; (2)5 Fluorouracil (5-FU) with or without methylcyclonitrosourea (MeCCNU); (3) Mitomycin with or without 5FU; (4) Doxorubicin-based regimen (if used 5FU and mitomycin). In the early 50’s, multiple agents such as thiotepa and 5-FU mitomycin were used. A single 5FU regimen did not improve the survival rate of curative resection. 5-FU and MeCCNU The report used by the joint has both agreed and disagreed. The relevant opinions are still inconsistent. Due to the different case selection methods, 5-FU has no benefit in combination with vinblastine, cyclophosphamide, or BCNU.