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内生致热原的发现,使发热发病学的研究,跨入一个新阶段。内生致热原的化学性质和生物学效应均与“细菌致热原”不同。动物和人体的多形核粒性白细胞和大吞噬单核细胞,都能产生和释放内生致热原。但首先必须被激活。作者和其他学者的实验资料证明,内生致热原可能是多种发热的基本机制中的“信息”分子。它最可能作用于丘脑下部,而Beceлкин的“反射始动机制”假说则是缺乏根据的。本文还介绍了近年来关于致热原作用方式的研究资料。
The discovery of endogenous pyrogen causes the study of fever and fever to enter a new phase. Endogenous pyrogen’s chemical properties and biological effects are different from the “pyrogenic bacteria.” Both polymorphonuclear leukocytes and macrophages in animals and humans produce and release endogenous pyrogen. But first it must be activated. The experimental data of the authors and other scholars have shown that endogenous pyrogen may be the “information” molecule in the basic mechanism of a variety of fever. It most likely acts on the hypothalamus, whereas Beceлкин’s hypothesis of “reflex initiation mechanism” is unfounded. This article also introduced the research data on pyrogenation mode in recent years.