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目前治疗肢端肥大症,不能摘除垂体腺瘤时,可用放疗。但有少数病例即使手术也不能完全摘除垂体腺瘤。因此,血中生长激素(GH)值虽比术前降低,仍常高于正常值。放疗出现效果又常需要多年。因此,对这种病例,如能通过药物抑制腺瘤分泌是再为理想的。 1972年意大利Liuzzi等发表了用多巴胺协同剂溴隐亭(CB-154)治疗肢端肥大症,使垂体腺瘤分泌GH下降。以后,本药就广泛用来治疗肢端肥大症,但有时无效。小剂量无效时虽可增加剂量而显效,但增加剂量会出现恶心或其他副作用。总之,本药能使血中GH降低者约60～70％。
The current treatment of acromegaly, pituitary adenoma can not be removed, the available radiotherapy. However, a small number of cases even if the surgery can not be completely removed pituitary adenoma. Therefore, the blood growth hormone (GH) value lower than the preoperative, often higher than normal. Radiation therapy often takes effect for many years. Therefore, in this case, such as through the inhibition of adenoma secretion of drugs is ideal. In 1972, Italy Liuzzi et al published acupuncture treatment of acromegaly with dopamine synergist bromocriptine (CB-154), which decreased the secretion of GH in pituitary adenomas. Later, the drug is widely used to treat acromegaly, but sometimes ineffective. Small dose ineffective although it can increase the dose and effective, but increasing the dose may appear nausea or other side effects. In short, the drug can make blood GH decreased by about 60 to 70%.