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目的:检测miR-21在重度子痫前期患者与正常孕妇胎盘组织中的表达差异。方法:收集2011年1月～2011年8月在江西省妇幼保健院产科行剖宫产的16例重度子痫前期患者和16例正常妊娠妇女的胎盘组织,通过实时荧光定量PCR技术检测胎盘组织中miR-21的表达水平。结果:miR-21在重度子痫前期患者胎盘组织中表达水平明显升高,为正常对照组表达水平的2.02倍(P<0.05)。结论:miR-21在胎盘组织中的表达水平可能与子痫前期的发生发展病理过程存在一定相关性。
Objective: To detect the expression of miR-21 in placenta of patients with severe preeclampsia and normal pregnant women. Methods: Placental tissues from 16 patients with severe preeclampsia and 16 normal pregnant women who underwent cesarean section in the Maternity and Child Health Hospital of Jiangxi Province from January 2011 to August 2011 were collected. The placental tissues were collected by real-time fluorescence quantitative PCR In miR-21 expression levels. Results: The expression level of miR-21 in placenta of patients with severe preeclampsia was significantly increased, which was 2.02 times that of the normal control group (P <0.05). Conclusion: The expression level of miR-21 in placenta may be related to the pathogenesis of preeclampsia.