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目的为了解决静脉注射纳络酮治疗缺血性脑卒中存在的问题。我们设计了颈动脉留置管注射纳络酮的方法。方法６０例缺血性脑卒中病人随机分为两组，颈动脉留置管注射纳络酮组（３０例）和静脉注射纳络酮组（３０例）。两组均于发病７２小时内开始治疗。结果颈动脉用药组的神经功能恢复程度明显优于静脉用药组（Ｐ＜０．０５）。住院１５天治愈率＋显著进步率：动脉用药组为６６．７％；静脉用药组为２３．３％（Ｐ＜０．０１）。结论颈动脉留置管的注射方法、使药物直接作用于病灶区，一次穿刺可以多次用药，安全可靠、简便易行，可缩短病程，尤其适用于发病早期的患者。
Objective To solve the problem of intravenous injection of naloxone in the treatment of ischemic stroke. We designed a method of injecting naloxone in the carotid catheter. Methods Sixty 60 patients with ischemic stroke were randomly divided into two groups: naloxone group (n = 30) and naloxone group (n = 30). Both groups began treatment within 72 hours of onset. Results The recovery of neurological function of the carotid artery medication group was significantly better than that of the intravenous medication group (P <0.05). 15 days hospitalization cure rate + significant progress rate: arterial drug group was 66.7%; intravenous drug group was 23.3% (P <0.01). Conclusion The injecting method of the carotid artery indwelling tube makes the drug act directly on the lesion area. The puncture can be used multiple times, which is safe, reliable, simple and easy to be performed, and shortens the course of the disease. It is especially suitable for patients with early onset.