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目的探讨不同疾病中肾小球滤过率(GFR)与多种因素关系。方法用99TcmDTPA清除率测定115例不同疾病所致的肾功能不全患者的GFR,并测血清肌酐(SCr)、尿素氮(BUN)、尿酸、K+、血红蛋白,并测心率、平均动脉压、体重指数、体表面积,记录患者的年龄。将不同病因的各组GFR分别与上述各临床因素进行简单相关分析,对与GFR有显著相关关系的上述临床因素再与GFR作多元相关分析。结果在不同疾病所致的肾功能不全患者中,除糖尿病外,其GFR始终与SCr呈显著负相关。结论在除外糖尿病的肾功能不全中,SCr是反映GFR的理想指标。
Objective To investigate the relationship between glomerular filtration rate (GFR) and various factors in different diseases. Methods GFR was measured in 99 patients with renal insufficiency caused by different diseases by 99TcmDTPA clearance rate. Serum creatinine (SCr), blood urea nitrogen (BUN), uric acid, K + and hemoglobin were measured. The heart rate, mean arterial pressure, body mass index , Body surface area, record the patient’s age. The different causes of GFR in each group and the above-mentioned clinical factors were simple correlation analysis, and GFR significant correlation between the above clinical factors and then GFR multivariate correlation analysis. Results In patients with renal insufficiency due to different diseases, except GFR, GFR always had a significant negative correlation with SCr. Conclusion SCr is an ideal indicator of GFR in renal dysfunction except diabetes.