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[目的]探讨卡维地洛对慢性充血性心力衰竭(chronicity congested heart failure)患者心室重塑和心功能的影响。[方法]慢性充血性心力衰竭患者125例随机分为A、B两组,均给予常规抗心衰治疗(洋地黄、利尿剂、血管扩张剂),B组同时加用卡维地洛,观察治疗(left ventricular end diastol diamete)、左室收缩末期内径(left ventricularend systolic diamete)及左室射血分数(left ventricular ejection fraction)。记录治疗前后两组心率、血压变化。[结果]与治疗前相比,B组左心室结构和功能均有明显改善,有统计学差异(P﹤0.05);A、B组间比较左心室结构和功能有差异,有统计学意义(P﹤0.05)。[结论]在洋地黄、利尿剂、血管扩张剂常规治疗基础上应用卡维地洛可显著改善慢性充血性心力衰竭患者心室重塑和心功能。
[Objective] To investigate the effect of carvedilol on ventricular remodeling and cardiac function in patients with chronic heart failure (congestive heart failure). [Methods] A total of 125 patients with chronic congestive heart failure were randomly divided into A and B groups. All patients were given conventional anti-heart failure treatment (digitalis, diuretic and vasodilator). In group B, carvedilol was added at the same time. Left ventricular end diastol diamete, left ventricular systolic diamete, and left ventricular ejection fraction. Before and after treatment, heart rate and blood pressure were recorded. [Results] Compared with those before treatment, the structure and function of left ventricle in group B were significantly improved (P <0.05), while the structure and function of left ventricle in group A and B were significantly different P <0.05). [Conclusion] The application of carvedilol on the basis of routine treatment of digitalis, diuretic and vasodilator can significantly improve ventricular remodeling and cardiac function in patients with chronic congestive heart failure.