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目的:检测JMJD6蛋白在胃癌组织及相应癌旁正常组织中的表达情况,并分析JMJD6蛋白表达与胃癌患者临床病理参数及预后的关系。方法:应用免疫组织化学方法检测JMJD6蛋白在胃癌组织及相应癌旁正常组织中的表达情况,进一步用Kaplan-Meier生存分析、COX比例风险回归模型等统计学方法研究JMJD6表达与胃癌患者临床病理参数及预后的关系。结果:JMJD6在胃癌组织中的表达阳性率显著高于癌旁正常组织(P=0.001);JMJD6在胃癌组织的高表达与肿瘤临床分期(P=0.008)、病理分级(P=0.001)、局部浸润深度(P=0.028)、有无淋巴结转移(P=0.001)等显著相关;Kaplan-Meier生存分析结果表明JMJD6高表达的胃癌患者术后总体生存率显著低于JMJD6低表达的患者(P=0.023)。结论:JMJD6在胃癌的发生发展中可能发挥了癌基因样作用,可能作为胃癌治疗的潜在靶点。
OBJECTIVE: To detect the expression of JMJD6 protein in gastric cancer tissues and adjacent normal tissues, and to analyze the relationship between the expression of JMJD6 protein and the clinicopathological parameters and prognosis of gastric cancer patients. Methods: The expression of JMJD6 protein was detected by immunohistochemistry in gastric cancer tissues and adjacent normal tissues. Kaplan-Meier survival analysis and COX proportional hazards regression model were used to study the relationship between JMJD6 expression and clinical pathological parameters And prognosis. Results: The positive expression rate of JMJD6 in gastric cancer tissues was significantly higher than that in adjacent normal tissues (P = 0.001). The high expression of JMJD6 in gastric cancer tissues was correlated with the clinical stage (P = 0.008), pathological grade (P = 0.001) Kaplan-Meier survival analysis showed that the overall survival rate of patients with JMJD6 overexpression was significantly lower than that of patients with low JMJD6 expression (P = 0.028), with or without lymph node metastasis (P = 0.001) 0.023). Conclusion: JMJD6 may play an oncogene-like role in the development of gastric cancer and may serve as a potential target for the treatment of gastric cancer.