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目的：了解脑脊液置换对蛛网膜下腔出血（ＳＡＨ）患者外周血一氧化氮（ＮＯ）和内皮素（ＥＴ）的影响。方法：对１７例ＳＡＨ患者进行脑脊液置换，并对治疗前后的ＮＯ和ＥＴ水平进行观察。结果：脑脊液置换后第４日和第７日外周血ＮＯ水平分别由（４．４５±１．０２）μｍｏｌ／Ｌ升高至（８．０１±１．０１）μｍｏｌ／Ｌ和（７．９３±１．８７）μｍｏｌ／Ｌ，差异有极显著性（Ｐ均＜０．０１）；ＥＴ水平由（１２．３２±２．２７）ｎｇ／Ｌ下降至（５．５６±０．７５）ｎｇ／Ｌ和（６．０２±１．１０）ｎｇ／Ｌ，差异有极显著性（Ｐ均＜０．０１）。结论：脑脊液置换是治疗ＳＡＨ的有效方法。
Objective: To investigate the effects of cerebrospinal fluid replacement on the levels of nitric oxide (NO) and endothelin (ET) in patients with subarachnoid hemorrhage (SAH). Methods: Cerebrospinal fluid replacement was performed in 17 patients with SAH. The levels of NO and ET before and after treatment were observed. Results: The levels of NO in the peripheral blood were increased from 4.45 ± 1.02 μmol / L to 8.01 ± 1.01 μmol / L and 7.93% after the CSF replacement ± 1.87) μmol / L, the difference was significant (P <0.01); ET decreased from (12.32 ± 2.27) ng / L to (5.56 ± 0.75) ng / L and (6.02 ± 1.10) ng / L, the difference was significant (P <0.01). Conclusion: Cerebrospinal fluid replacement is an effective method for the treatment of SAH.