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目的探讨DOG1在CD117/CD34阴性的胃肠道间质瘤(GIST)诊断中的价值。方法采用免疫组化S-P法检测72例GIST和9例胃肠外GIST中DOG1、CD117、CD34、SMA、S100的表达情况。结果 CD117在GIST和胃肠外GIST中表达率分别为88.9%和77.8%,CD34在GIST和胃肠外GIST中表达率分别为72.2%和44.4%,而DOG1在GIST和胃肠外GIST中表达率分别为93.0%和100%。8例CD117阴性病例中,DOG1阳性表达率为37.5%(3/8)。DOG1和CD117阳性表达率在各风险程度组两两比较差异均未见统计学意义(P>0.05)。结论 DOG1在诊断GIST中与CD117、CD34有一定互补性,在GIST的诊断、鉴别诊断工作中是一种很有价值的抗体。
Objective To investigate the value of DOG1 in the diagnosis of CD117 / CD34 negative gastrointestinal stromal tumors (GIST). Methods The expression of DOG1, CD117, CD34, SMA and S100 in 72 cases of GIST and 9 cases of parenteral GIST were detected by immunohistochemical S-P method. Results The positive rate of CD117 expression in GIST and GIST was 88.9% and 77.8%, respectively. The expression rates of CD34 in GIST and GIST were 72.2% and 44.4%, respectively. However, the expression of DOG1 in GIST and GIST Rates were 93.0% and 100% respectively. In 8 cases of CD117 negative cases, the positive rate of DOG1 expression was 37.5% (3/8). The positive rates of DOG1 and CD117 in each risk group were no significant difference (P> 0.05). Conclusion DOG1 has certain complementarity with CD117 and CD34 in the diagnosis of GIST. It is a valuable antibody in the diagnosis and differential diagnosis of GIST.