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目的探讨联合检测C反应蛋白(CRP)和降钙素原(PCT)在儿童急性淋巴细胞白血病(ALL)白细胞减少合并感染中的临床意义。方法选取2013年12月-2015年12月入院44例ALL白细胞减少合并感染患儿作为感染组,选取同期在门诊复查的ALL未出现并发症的儿童40例作为对照组,比较两组研究对象血清CRP、PCT水平差异。结果感染组患儿血清CRP、PCT水平较对照组显著升高,差异均有统计学意义(t=4.871、3.487,P<0.05)。感染组血清CRP、PCT检测的阳性率明显高于对照组,差异有统计学意义(P<0.05),CRP+PCT联合检测的阳性率为79.55%,显著高于CRP、PCT单独检测(P<0.05)。感染单项指标中,CRP的敏感性较高,PCT特异性较好,综合评价各项性能指标,CRP+PCT联合检测的性能指标更佳。结论在儿童ALL白细胞减少合并感染中,联合检测血清CRP和PCT可提高临床对感染的诊断效率。
Objective To investigate the clinical significance of combined detection of C-reactive protein (CRP) and procalcitonin (PCT) in the co-infection of leukemia in children with acute lymphoblastic leukemia (ALL). Methods From December 2013 to December 2015, 44 children with ALL leukopenia and infection were selected as infection group. Forty children with no complications who were diagnosed in outpatients during the same period were selected as control group. CRP, PCT level differences. Results The levels of serum CRP and PCT in the infected group were significantly higher than those in the control group (t = 4.871, 3.487, P <0.05). The positive rates of serum CRP and PCT in the infected group were significantly higher than those in the control group (P <0.05). The positive rate of CRP + PCT was 79.55%, significantly higher than that of CRP and PCT (P < 0.05). CRP sensitivity is higher and PCT specificity is better in single infection index. Comprehensive evaluation of each performance index, CRP + PCT combined detection of better performance indicators. Conclusion Combined detection of serum CRP and PCT in children with ALL leukopenia can improve the diagnostic efficiency of clinical infection.