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目的 探讨奥曲肽（Ｏｃｔｒｅｏｔｉｄｅ） 对胰十二指肠切除术后并发症的防治作用及作用机理。方法 对１９９０ 年１ 月至１９９８ 年６ 月行胰十二指肠切除术的９６ 例患者术后每日消化液量、严重并发症等作回顾性分析。 结果 在术后１ 周内，平均每日消化液量为：奥曲肽组（５８ 例）胰液（５３±８） ｍｌ，胆汁（１７２±２７） ｍｌ，胃液（２１２±３９） ｍｌ，对照组（３８ 例） 胰液（２６８±４６） ｍｌ，胆汁（３８５±５２） ｍｌ，胃液（３１８ ±６０） ｍｌ，奥曲肽组显著少于对照组（Ｐ＜０－０１） ；奥曲肽组严重并发症发生率１４ ％ ，对照组３７％ ，奥曲肽组显著低于对照组（χ２＝ ６－９０，Ｐ＜ ０－０１） ；手术死亡率（２％ ） 也低于对照组（１０％） 。 结论 奥曲肽通过减少多种消化液量及胰液中胰酶的浓度等途径，在一定程度上能预防或降低胰十二指肠切除术后严重并发症的发生率
Objective To investigate the preventive and therapeutic effects of octreotide on complications after pancreatoduodenectomy. Methods The daily digestive fluid volume and serious complications of 96 patients undergoing pancreatoduodenectomy from January 1990 to June 1998 were analyzed retrospectively. Results The average daily digestive fluid volume in the first week postoperatively was: octreotide group (58 cases) pancreatic fluid (53±8) ml, bile (172±27) ml, gastric juice (212±39) ml, control group (38 Example) Pancreatic juice (268±46) ml, bile (385±52) ml, gastric juice (318±60) ml, octreotide group was significantly less than control group (P<0-01); octreotide group severe complication rate was 14% In the control group, 37%, the octreotide group was significantly lower than the control group (χ2=6-90, P<0-01); the operative mortality (2%) was also lower than the control group (10%). Conclusion Octreotide can prevent or reduce the incidence of severe complications after pancreatoduodenectomy to some extent by reducing the amount of various digestive fluids and the concentration of trypsin in pancreatic juice.