论文部分内容阅读
目的探讨唐山地区流感病毒的病原学特征。方法采集哨点医院流感样病例的咽拭子标本,采用实时荧光PCR方法检测流感病毒核酸。结果 2009年-2015年采集的8 691例流感样病例标本中,经流感病毒核酸检测阳性1 315例,阳性率为15.13%,其中甲型H1N1为594例、季节性H3N2为460例、乙型261例。不同季节、不同年度优势病原不同;连续6年的监测中除了2009年-2010年流感提前流行外,多数年份流感高发期为每年的12月-次年3月。季节性H3N2和乙型流感病毒均有不同程度的流行,其中季节性H3N2和乙型流感病毒分别为2014年-2015年和2011年-2012年的优势病原,此期间未检测到甲型H1N1病毒。结论唐山地区流感高发期为每年12月-次年3月,病原为甲型H1N1、季节性H3N2和乙型病毒,甲型H1N1流感具有阶段性特征,每流行2年间歇1年。
Objective To explore the etiological characteristics of influenza virus in Tangshan area. Methods The throat swab samples from the sentinel hospital were collected, and the influenza virus nucleic acid was detected by real-time fluorescence PCR. Results Among 8 691 influenza-like cases collected from 2009 to 2015, 1 315 positive samples were detected by influenza virus nucleic acid and the positive rate was 15.13%, including 594 cases of type A H1N1, 460 cases of seasonal H3N2, 261 cases. In different seasons, the predominant pathogens are different in different years. In addition to the prevalent epidemic of 2009-2010 in the monitoring of 6 consecutive years, the most frequent influenza in most years is from December to next March. Seasonal H3N2 and Influenza B viruses have varying degrees of prevalence, with seasonal H3N2 and Influenza B viruses being the predominant pathogens in 2014-2015 and 2011-2012, respectively, during which no A / H1N1 virus was detected . Conclusions The incidence of influenza in Tangshan area is from December to March each year. The pathogen is type A H1N1, seasonal H3N2 and type B virus. Influenza A (H1N1) has periodic characteristics, with an interval of 1 year each for 2 years.