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为研究NPY对粘膜纤毛运动的影响,并确定此影响能否为α-肾上腺能受体或Ca~(++)阻滞剂所阻断,作者选用家兔,面或舌动脉逆行性插管给药,管尖接近上颌动脉,上颌窦粘膜用环钻法暴露2×8mm,并立即盖上防雾窗,用双目显微镜观察粘膜纤毛运动,光电法记录结果,粘膜纤毛运动形式由示波器连续监测,墨水探笔记录,统计纤维运动频率进行计算机分析,同时监测ECG、体温、呼吸和血压。先定出纤毛运动频率基线零点,实验如下进行:①8只兔,增加NPY剂量(0.0001～5.0μg/kg),观察对粘膜纤毛运动的影响;②6只兔,连续
To investigate the effect of NPY on mucociliary movement and to determine whether this effect is blocked by alpha-adrenoceptors or Ca ++ blockers, we selected retrograde intubation of rabbit, facial or lingual arteries The catheter tip was close to the maxillary artery. The mucosa of the maxillary sinus was exposed to 2 × 8 mm with a ring drill. Immediately, the anti-fog window was covered. The mucociliary movement was observed with a binocular microscope. The results of the photoelectric method were recorded. Monitoring, ink probe recording, statistical fiber movement frequency computer analysis, while monitoring ECG, body temperature, respiration and blood pressure. First set the ciliary motion frequency baseline zero, the experiment was as follows: ① 8 rabbits, increased NPY dose (0.0001 ~ 5.0μg / kg), mucosal ciliary movement observed; ② 6 rabbits, continuous