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目的研究镧（Ｌａ）、铈（Ｃｅ）元素对小鼠局部毒性的组织变化及其对全身的急性毒性作用。方法用浓度分别为０．２％和１％的镧（Ｌａ）、铈（Ｃｅ）防龋溶液涂擦小鼠口腔颊粘膜，观察其涂药后的全身状况及不同阶段的局部组织学变化。结果涂药后的小鼠无全身急性中毒反应。组织学观察发现，绝大多数小鼠颊粘膜结构无明显变化，仅少数出现轻微炎症反应，但与对照组相比无统计学差异。结论０．２％和１％的Ｌａ、Ｃｅ溶液涂擦小鼠颊粘膜是安全的，并将可能成为一类较为安全的局部应用的防龋药物
Objective To study the tissue changes of local toxicity of La and Ce on mice and its acute toxicity to the whole body. Methods The buccal mucosa of mice were rubbed with lanthanum (La) and cerium (Ce) anti-caries solutions at concentrations of 0.2% and 1%, respectively. The systemic conditions and the local histological changes at different stages were observed. Results The mice after application had no systemic acute poisoning reaction. Histological observation found that the vast majority of mice buccal mucosa structure no significant change, only a small number of mild inflammatory reactions, but compared with the control group no significant difference. Conclusions 0.2% and 1% La and Ce solutions are safe for rubbing mouse buccal mucosa and may be a more safe topical anticaries agent