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目的:评价红花注射液在治疗急性脑梗死的疗效及其对实验室检测S100β蛋白浓度的影响,从而为临床医师提供科学的参考依据。方法:参考国内外有关性能评价的文件和报道,抽取入院的急性脑梗死患者80例,随机分为对照组(常规治疗)和治疗组(常规治疗+红花注射液治疗)及健康人群进行S100β蛋白的检测分析。结果:对照组和治疗组分别与健康人群S100β蛋白水平相比较,差异均有统计学意义(P<0.01);治疗组总有效率明显高于对照组,差异有统计学意义;与治疗前比较对照组及治疗组治疗7天、14天的血清S100β蛋白水平均有降低,但治疗组与对照组比较100β蛋白水平下降更为明显,差异有统计学意义;与治疗前比对照组及治疗组治疗7天、14天的神经功能缺损程度评分(NSS)均有下降,但治疗组与对照组比较下降更明显,差异有统计学意义。结论:在常规治疗基础上联合红花注射液治疗急性脑梗死效果更佳,且可以更加有效降低血清S100β蛋白的水平。
Objective: To evaluate the curative effect of safflower injection in the treatment of acute cerebral infarction and its effect on the concentration of S100β in the laboratory, so as to provide scientific reference for clinicians. Methods: According to the documents and reports about performance evaluation at home and abroad, 80 patients with acute cerebral infarction admitted to hospital were randomly divided into control group (conventional treatment) and treatment group (conventional treatment + safflower injection treatment) and healthy population S100β Detection and Analysis of Proteins. Results: The levels of S100β protein in control group and treatment group were significantly different from those in healthy group (P <0.01). The total effective rate in treatment group was significantly higher than that in control group, and the difference was statistically significant. Compared with pre-treatment Compared with the control group and the treatment group, the levels of S100β protein in the serum of the control group and the treatment group decreased after 7 days and 14 days respectively, but the levels of 100β protein in the treatment group and the control group decreased more significantly After 7 days and 14 days, the neurological deficit score (NSS) decreased, but the difference between the treatment group and the control group was more obvious, the difference was statistically significant. Conclusion: The combination of safflower injection on the basis of conventional treatment is more effective in treating acute cerebral infarction, and can reduce the serum S100β protein level more effectively.