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目的:探讨研究分泌性中耳炎患者外周血T淋巴细胞亚群及免疫球蛋白水平变化。方法:选取2008-12/2010-06进行治疗的50例分泌性中耳炎患者为研究对象,将其设为观察组,同时选取同期的50名健康人为对照组,分别检测两组人员外周血T淋巴细胞亚群及免疫球蛋白水平进行检测及比较。结果:经比较发现,观察组患者CD3+、CD4+及CD8+水平均明显低于对照组,CD4+/CD8+水平则高于对照组,同时血清IgA、IgG、IgM及C3、C4水平也一定程度上均高于对照组,且急性患者水平与慢性患者也有一定差异,经比较,有显著性差异或有非常显著性差异(P<0.05或P<0.01)。结论:分泌性中耳炎患者外周血T淋巴细胞亚群及免疫球蛋白水平均有一定的变化,对于了解患者的发展状况及严重程度等均有积极的意义,因此其水平检测值得临床进一步研究及探讨。
Objective: To investigate the changes of peripheral blood T lymphocyte subsets and immunoglobulin levels in patients with secretory otitis media. Methods: Fifty patients with secretory otitis media who were treated from 2008-12 / 2010-06 were selected as the observation group and 50 healthy people in the same period were selected as the control group. T lymphocytes Cell subsets and immunoglobulin levels were detected and compared. Results: Compared with the control group, the levels of CD3 +, CD4 + and CD8 + in the observation group were significantly lower than those in the control group, while the levels of CD4 + / CD8 + were higher than those in the control group In the control group, there was also a significant difference between acute patients and chronic patients. There were significant differences or significant differences between the two groups (P <0.05 or P <0.01). Conclusion: There are some changes in peripheral blood T lymphocyte subsets and immunoglobulin levels in patients with secretory otitis media, which have a positive meaning for understanding the development status and severity of patients, so the level of T lymphocyte subsets should be further studied and discussed .