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目的分析不同病毒感染类型的手足口病(HFMD)患儿红细胞锌浓度及免疫球蛋白IgG亚类的表达变化及相互关系,为患儿病情进展预测提供依据。方法选取2011年3月—2013年3月在湖北省孝感市中心医院诊治的手足口病患儿1756例作为研究对象,按病情分为3组,普通病例组(普通组)、病情加重组(加重组)及重型病例组(重症组),检测红细胞锌浓度、血免疫球蛋白IgG亚类浓度及所感染病毒类型,分析红细胞锌浓度、血免疫球蛋白IgG亚类浓度在预测不同病毒感染类型的手足口病(HFMD)患儿病情发展中的作用。结果普通组、加重组与重型组的红细胞锌浓度分别为(117.9±61.7)μmol/L、(93.2±40.6)μmol/L与(85.2±41.7)μmol/L,IgG1浓度分别为(5.81±1.54)g/L、(4.16±1.27)g/L与(4.02±1.13)g/L,经方差分析,差异均有统计学意义(P<0.05);加重组患儿,EV71组在入院时的红细胞锌、IgG1浓度分别为(113.5±51.5)μmol/L、(5.73±1.52)g/L,而病情转变为重症后,浓度分别为(85.0±36.5)μmol/L、(3.78±1.23)g/L,经t检验,差异均有统计学意义(P<0.05)。结论血浆中红细胞锌浓度和免疫球蛋白IgG1联合检测可以对EV71型病毒引起的HFMD患儿病情的进展起一定预测作用,及时检测可以发现不良预后趋势。
Objective To analyze the changes of erythrocyte zinc levels and immunoglobulin IgG subclasses in children with HFMD and to find out the relationship between them and the prognosis of children with HFMD. Methods A total of 1756 hand-foot-mouth disease patients diagnosed and treated in Xiaogan Central Hospital of Hubei Province from March 2011 to March 2013 were selected as the research objects. The patients were divided into three groups according to their illness: common case group, exacerbation group (Severe group) and severe case group (group of severe). The concentrations of zinc in erythrocytes, IgG subclass of immunoglobulin and the type of virus were detected. The concentrations of zinc in erythrocytes and IgG subclasses in serum were determined in different types of virus infection Of hand foot and mouth disease (HFMD) in children with the role of development. Results The levels of erythrocyte zinc in normal group, severe group and severe group were (117.9 ± 61.7) μmol / L, (93.2 ± 40.6) μmol / L and (85.2 ± 41.7) μmol / L respectively, and IgG1 concentrations were (5.81 ± 1.54 (4.16 ± 1.27) g / L and (4.02 ± 1.13) g / L, respectively. There was significant difference between the two groups (P <0.05) The concentrations of erythrocyte zinc and IgG1 were (113.5 ± 51.5) μmol / L and (5.73 ± 1.52) g / L, respectively, while those of severe erythrocytes were (85.0 ± 36.5) μmol / L and (3.78 ± 1.23) g / L, after t test, the differences were statistically significant (P <0.05). Conclusion The combination of zinc concentration in erythrocytes and immunoglobulin IgG1 in plasma may play a role in predicting the progression of HFMD in children with EV71 virus. A timely detection may find a negative prognosis.