论文部分内容阅读
目的评估辛伐他汀对矽肺患者的疗效。方法 40例单纯矽肺患者常规治疗为对照组,40例矽肺合并高血脂患者常规治疗的基础上加用辛伐他汀降血脂治疗为观察组,治疗期间观察患者降血脂的同时观察矽肺相关的临床症状及实验室检查。根据疗效标准对辛伐他汀的矽肺治疗作用进行评估。结果观察组和治疗组总有效率分别为87.5%、65.0%(P<0.05)。两组患者治疗后血气分析指标组间比较及与本组治疗前比较,差异均有统计学意义(P<0.05)。结论辛伐他汀不仅具有良好的降血脂作用,对合并高血脂患者具有改善肺通气,减轻矽肺相关的临床症状。主张合并高血脂者积极降血脂治疗,单纯矽肺患者有待于扩大样本进行前瞻性研究。
Objective To evaluate the effect of simvastatin on patients with silicosis. Methods 40 cases of simple silicosis patients as control group, 40 cases of silicosis with hyperlipidemia patients on the basis of conventional treatment plus simvastatin lipid-lowering treatment for the observation group during the treatment of patients with hypolipidemic observation of silicosis-related clinical symptoms And laboratory tests. The therapeutic effect of simvastatin on silicosis was evaluated according to the efficacy criteria. Results The total effective rate in observation group and treatment group was 87.5% and 65.0% respectively (P <0.05). Two groups of patients after treatment, blood gas analysis index comparison between groups and compared with this group before treatment, the difference was statistically significant (P <0.05). Conclusion Simvastatin not only has good hypolipidemic effect, but also can improve lung ventilation and alleviate the clinical symptoms associated with silicosis in patients with hyperlipidemia. Advocate the active treatment of hyperlipidemia hypoglycemic treatment, patients with silicosis to be expanded sample for prospective study.