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本文检测了11例暴发性乙型肝炎病人血清的抗-前S_1、抗-前S_2的IgM、IgA、IgG类抗体,以及IgA-(1、2)和S IgA,并同7例非暴发性急性乙型肝炎病人进行比较。暴发性肝炎诊断依据:(1)发病8周内进展为2～4期肝性脑病;(2)凝血酶原<40%;(3)IgM抗-HBc高滴度;(4)以往无肝病史,或使用具有肝毒性或免疫调节药物史。用反向被动血凝法检测HBsAg;被动血凝法检测抗-HBs;用市售药盒测定e系统及δ抗体,用固相酶免疫法测定IgM
In this paper, anti-pre-S 1, anti-pre-S 2 IgM, IgA, IgG antibodies, as well as IgA- (1, 2) and S IgA were detected in serum of 11 patients with fulminant hepatitis B and 7 non-fulminant Acute hepatitis B patients were compared. The diagnosis of fulminant hepatitis is based on: (1) progression to 2 to 4 stages of hepatic encephalopathy within 8 weeks of onset; (2) prothrombin <40%; (3) high titer of IgM anti-HBc; (4) History, or use of drugs with hepatotoxicity or immunomodulation history. HBsAg was detected by reverse passive hemagglutination, anti-HBs by passive hemagglutination, e-system and delta-antibody were detected by commercial kits, and IgM