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一般认为哮喘与支气管收缩剂的过度反应密切相关。但偶尔也见某些哮喘者无这种过度反应性。业已表明过度反应性的缺如可能是假象,与FEV_1测量法有关。因FEV_1测量需要一次最大吸气,而后者扩张某些哮喘者收缩的气道,并可防止吸入支气管收缩剂后的FEV_1明显下降。本文不用预先最大吸气的方法而用比气道传导检测法(SRaw)观察3例哮喘者对碳酰胆碱的反应,结果出现哮喘症状而无气道过度反应。确诊为哮喘患者3例在停用β肾上腺素能支气管扩张药及皮质激素类药后吸入碳酰胆碱3 m g,6～18个月后重复此激发试验。于每次吸入前后分别测量SRaw。本文认为吸入碳酰胆碱3 mg 后,SRaw 增加低于50%者为非哮喘反应。
It is generally believed that asthma and bronchoconstrictor overreaction is closely related. But occasionally see some asthma without this overreactivity. It has been shown that the absence of overreactivity may be an illusion associated with the FEV_1 measure. The FEV_1 measurement requires a maximum inspiratory effort, while the latter dilates the contracted airways in some asthmatic subjects and prevents a significant decrease in FEV_1 after inhaled bronchoconstrictor. This article does not use the method of pre-maximum aspiration with the airway conduction test (SRaw) observed in 3 asthmatic patients on the reaction of carbachol, asthma symptoms without airway hyperresponsiveness. Three patients diagnosed with asthma inhaled carbachol 3 m g after discontinuation of β-adrenergic bronchodilators and corticosteroids, and the challenge test was repeated 6 to 18 months later. SRaw was measured before and after each inhalation. This article suggests that inhalation of carbachol 3 mg, SRaw increased less than 50% were non-asthmatic reactions.