PTEN inhibition and axon regeneration and neural repair

• 作 者: Yosuke Ohtake Umar Hayat Shuxin Li
• 机 构: Shriners Hospitals Pediatric Research Center, Department of Anatomy and Cell Biology, Temple Univers
• 出 处: 中国神经再生研究（英文版）
• 发表日期: 2015年9期
• 关键词: PTEN inhibition antagonist peptide spinal cord injury intrinsic growth capacity

The intrinsic growth ability of all the neurons declines during development although some may grow better than others. Numerous intracellular signaling proteins and transcription factors have been shown to regulate the intrinsic growth capacity in mature neurons. Among them, PI3 kinase/Akt pathway is important for controlling axon elongation. As a negative regulator of this pathway, the tumor suppressor phosphatase and tensin homolog (PTEN) appears critical to con-trol the regenerative ability of young and adult neurons. This review will focus on recent research progress in axon regeneration and neural repair by PTEN inhibition and therapeutic potential of blocking this phosphatase for neurological disorders. Inhibition of PTEN by deletion in con-ditional knockout mice, knockdown by short-hairpin RNA, or blockade by pharmacological approaches, including administration of selective PTEN antagonist peptides, stimulates various degrees of axon regrowth in juvenile or adult rodents with central nervous system injuries. Im-portantly, post-injury PTEN suppression could enhance axonal growth and functional recovery in adult central nervous system after injury.