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目的探讨血浆D-二聚体水平与化疗前复发及转移性不可切除的晚期结直肠癌患者预后相关性。方法测定40例复发转移性结直肠癌患者化疗前血浆D-二聚体水平,分析其与临床病理因素及化疗疗效的相关性。结果血浆D-二聚体高表达患者生存期较中、低表达者短;血浆D-二聚体表达水平是患者死亡的独立预测因子;血浆D-二聚体表达水平与化疗疗效相关(P<0.05)。结论复发转移性结直肠癌患者血浆D-二聚体高表达者生存率较低,血浆D-二聚体水平可作为转移性结直肠癌患者系统化疗效果的预测指标之一。
Objective To investigate the relationship between plasma D-dimer level and the prognosis of patients with unresectable and unresectable advanced colorectal cancer before chemotherapy. Methods The levels of plasma D-dimer in 40 patients with recurrent metastatic colorectal cancer before chemotherapy were determined and their correlations with clinicopathological parameters and chemotherapy efficacy were analyzed. Results The survival time of patients with high D-dimer expression was shorter than those with moderate or low expression of D-dimer. The plasma D-dimer level was an independent predictor of death. The plasma D-dimer level was correlated with the efficacy of chemotherapy (P < 0.05). Conclusions The survival rate of patients with recurrent metastatic colorectal cancer with high expression of D-dimer is low, and plasma D-dimer level may be used as one of the predictors of systemic chemotherapy in patients with metastatic colorectal cancer.