Influence of different layers of skin on the percutaneous absorption of drugs with different lipophi

• 作 者: 李国锋 神山文男 等
• 机 构: DepartmentofClinicalPharmacology,DepartmentofBiopharmaceutics
• 出 处: 中国人民解放军军医大学学报：英文版
• 发表日期: 2002年2期
• 关键词: 角质层 经皮吸收 亲脂类药物 stratum corneum percutaneous absorption solubility lipophilici

<正>Objectives: To evaluate the barrier function of different skin layers in the process of percutaneous drug absorption. Methods: In vitro permeability via intact or stripped skin of 6 drugs (5-fluorouracil, theo-phylline, hydroquinone, barbital, is