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迄今，氟化物在体内、外的遗传毒性生物测试系统中所得的结果不尽一致，仍存在争论。本实验进行了氟化钠的果蝇伴性隐性致死交变研究，成年ＯＫ品系雄蝇被饲予含７２、１４４和２８８ＰＰＮａＦ（分别相当于１／８、１／４和１／２ＬＣ５０）的２％蔗糖液，连续４８小时。结果表明２８８ＰＰＮａＦ组的总致死率达０．５９％，与溶剂对照组之间存在显著性差异（Ｐ＜０．０５）．同时，各浓度组间也有肯定的剂量一效应关系。上述观察结果提示ＮａＦ为一弱致突变物，对人类生殖细胞可能具有潜在的遗传毒性作用，因此，必须作进一步研究，以确定氟化物的此种作用。
To date, there is a debate about the inconsistent results of fluoride in bioassay systems for genotoxicity in vivo and in vitro. In this experiment, we studied the alternating recessive lethality of Drosophila in sodium fluoride. Male adult OK strain was fed with 72, 144 and 288 PPNaF (corresponding to 1/8, 1/4 and 1/2 LC50 respectively) 2% sucrose solution for 48 hours. The results showed that the total lethality of 288PPNaF group was 0.59%, which was significantly different from that of the solvent control group (P <0.05). At the same time, there was also a positive dose-response relationship among each concentration group. These observations suggest that NaF is a weak mutagen that may have a potential genotoxic effect on human germ cells and therefore further studies must be conducted to determine this effect of fluoride.