Scutellaria baicalensis in Stroke Management:Nature's Blessing in Traditional Eastern Medicine

• 作 者: Bhakta Prasad Gaire Sang-Kwan Moon Hocheol Kim
• 机 构: Department of Herbal Pharmacology,College of Korean Medicine,Kyung Hee University,Seoul 130-701,Kore
• 出 处: Chinese Journal of Integrative Medicine
• 发表日期: 2014年09期
• 关键词: Scutellaria flavonoids baicalein allergic neuronal baicalin Eastern extracts her

Scutellaria baicalensis Georgi is the most widely used medicinal plant in traditional Eastern medicine,especially in Chinese medicine.The major phytochemicals isolated from S.baicalensis are flavonoids,glycosides and their glucoronides such as baicalin,baicalein,wogonin etc.More than 30 different kinds of flavonoids are isolated from this plant.S.baicalensis and its flavonoids are reported to have several pharmacological activities,which includes anti-allergic,antioxidant,anti apoptic,anti-inflammatory effects and many more.Recently,S.baicalensis and its isolated flavonoids have been studied for their neuroprotective effects,through a variety of in vitro and in vivo models of neurodegenerative diseases,plausibly suggesting that S.baicalensis has salutary effect as a nature’s blessing for neuroprotection.In this review,we are focousing on the neuroprotective effects of S.baicalensis and its flavonoids in ischemia or stroke-induced neuronal cell death.We aimed at compiling all the information regarding the neuroprotective effect of S.baicalensis in various experimental models of cerebral ischemia or stroke.

Scutellaria baicalensis Georgi is the most widely used medicinal plant in traditional Eastern medicine, especially in Chinese medicine. The major phytochemicals isolated from S.baicalensis are flavonoids, glycosides and their glucoronides such as baicalin, baicalein, wogonin etc.More than 30 different kinds of flavonoids are isolated from this plant.S.baicalensis and its flavonoids are reported to have several pharmacological activities, which includes anti-allergic, antioxidant, anti apoptic, anti-inflammatory effects and many more. been studied for their neuroprotective effects, through a variety of in vitro and in vivo models of neurodegenerative diseases, plausibly suggesting that S. baicalensis has salutary effect as a nature’s blessing for neuroprotection. In this review, we are fochering on the neuroprotective effects of S .baicalensis and its flavonoids in ischemia or stroke-induced neuronal cell death. We aimed at compiling all the inform ation regarding the neuroprotective effect of S. baicalensis in various experimental models of cerebral ischemia or stroke.