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尽管进行了广泛的努力,克隆病的病因目前仍不肯定。从传染和免疫角度进行研究,亦不能清晰解释该病的发病机理。前列腺素代谢在该病中有改变,但一般认为系炎症的继发性病变而不是克隆病的病因。克隆病的病因及发病机理虽然复杂,作者认为小肠紧密接合部异常而通透性增加可能起一定的作用。通透性增加使抗原和感染因子得以通过小肠肠壁,并在易感者形成病变。正常小肠上皮进行选择性吸收,通透性增加时使某些物质较容易地透过,由于这时肠屏障破坏不再能阻止这些物质进入。小肠通透性增加可影响细胞和细胞旁两条途径。小
Despite extensive efforts, the etiology of Crohn’s disease remains uncertain. Studies from the perspective of infection and immunization do not clearly explain the pathogenesis of the disease. Prostaglandin metabolism changes in the disease, but is generally believed to be secondary to inflammation and not the cause of Crohn’s disease. Although the etiology and pathogenesis of Crohn’s disease are complex, the author believes that the abnormality of the tight junction of the small intestine and the increased permeability may play a role. Increased permeability allows antigens and infectious agents to pass through the small bowel wall and cause lesions in susceptible individuals. Normal intestinal epithelium is selectively absorbed and some substances are more easily transmitted as the permeability increases, since then the intestinal barrier disruption can no longer prevent the entry of these substances. Increased intestinal permeability can affect both cells and paracellular pathways. small