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目的:探讨谷氨酰胺颗粒对化疗致肠道损伤的预防作用。方法:在我科2015年3月到2016年1月期间诊治的肺癌化疗患者中,抽取48例作为研究对象,并参照随机抽签原则分组,观察组(n=24)在化疗的基础上加用谷氨酰胺颗粒治疗,对照组(n=24)单纯进行化疗,对比2组患者化疗前后的部分毒性反应以及谷氨酰胺浓度变化。结果:(1)观察组化疗后的谷氨酰胺浓度远高于对照组(P<0.05);(2)观察组ALT、白细胞计数与化疗前相比无明显变化(P>0.05),而对照组ALT升高(P<0.05),白细胞计数降低(P<0.05)。结论:谷氨酰胺颗粒可提升肿瘤患者化疗后的血浆谷氨酰胺浓度,对预防化疗致肠道损伤有积极作用。
Objective: To investigate the preventive effect of glutamine on intestinal injury induced by chemotherapy. Methods: Forty-six patients with lung cancer undergoing chemotherapy from March 2015 to January 2016 were selected as the study subjects and divided into groups by random sampling. The observation group (n = 24) was treated on the basis of chemotherapy In the control group (n = 24), chemotherapy alone was used to compare the partial toxicity before and after chemotherapy and the change of glutamine concentration in two groups. Results: (1) The concentration of glutamine in the observation group after chemotherapy was much higher than that in the control group (P <0.05). (2) The ALT and leukocyte count in the observation group had no significant change compared with that before chemotherapy (P> 0.05) Group ALT increased (P <0.05), white blood cell count decreased (P <0.05). Conclusion: Glutamine granules can increase the concentration of plasma glutamine in patients with cancer after chemotherapy, which has a positive effect on the prevention of intestinal damage caused by chemotherapy.