Targeting the phosphoinositide-3-kinase/protein kinase B pathway in airway innate immunity

• 作 者: Indiwari Gopallawa Robert J Le
• 机 构: DepartmentofOtorhinolaryngology,DepartmentofOtorhinolaryngologyandDepartmentofPhysiology
• 出 处: 世界生物化学杂志:英文版(电子版)
• 发表日期: 2020年2期
• 关键词: Lung Nitric oxide synthase Nuclear factor erythroid 2 related factor-2 Respirato
• 基金项目: The United States National Institutes of Health,No.R01DC016309,The United States Cystic Fibrosis Foundation,No.GOPALL19F0.

The airway innate immune system maintains the first line of defense against respiratory infections.The airway epithelium and associated immune cells protect the respiratory system from inhaled foreign organisms.These cells sense pathogens via activation o