角膜植片上的“碎泥巴”样环丙沙星沉积物

• 作 者: Tanhehco T.Y. Chiavetta III S.V. Lee P.P. et al. N.A. Afshari 杨建刚
• 机 构: Duke University Eye Center DUMC Box 3802 Durham NC 27710 United States Dr. ,
• 出 处: 世界核心医学期刊文摘.眼科学分册
• 发表日期: 2005年09期
• 关键词: 角膜植片 沉积物 环丙沙星 喹诺酮类抗生素 角膜溃疡穿孔 非生理性 上皮缺损 药物成分 角膜 特殊病例

The authors describe an extreme case of ciprofloxacin deposition on the corneal graft of a 67-year-old man with a history of penetrating keratoplasty for corneal ulcer and perforation, who presented with dense, gray deposits on the anterior corneal surface after being treated with ciprofloxacin for an epithelial defect. The deposits resolved after ciprofloxacinwas discontinued. The non-physiologic pH of the drug formulation is thought to trigger corneal precipitates, and it remains to be seen whether fourth-generation fluoroquinoloneswill have a lower incidence of ocular precipitates.

The authors describe an extreme case of ciprofloxacin deposition on the corneal graft of a 67-year-old man with a history of penetrating keratoplasty for corneal ulcer and perforation, who presented with dense, gray deposits on the anterior corneal surface after being treated with ciprofloxacin The non-physiologic pH of the drug formulation is thought to trigger corneal precipitates, and it remains to be seen that fourth-generation fluoroquinolones have a lower incidence of ocular precipitates.