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目的探析B淋巴细胞表型(CD19~+、CD19~+CD25~+)与免疫五项(IgA、IgG、IgM与补体C3、C4)在新生儿缺氧缺血性脑病(HIE)患儿中的变化情况,以期为HIE患儿的预防与治疗提供一定的理论依据。方法分析2015年2月-2017年4月在该院接受诊治的72例HIE患儿(HIE组)的临床资料。另外选取同期在该院产科正常足月出生的70例新生儿(对照组)。比较两组新生儿的基线资料、B淋巴细胞表型及免疫五项的表达水平。比较轻、中、重度HIE患儿的B淋巴细胞表型及免疫五项的表达水平。结果两组新生儿的性别、胎龄、日龄等基本资料比较,差异均无统计学意义(均P>0.05);HIE组患儿CD19~+、CD19~+CD25~+、IgA、补体C3及C4水平均明显低于对照组(均P<0.01);两组新生儿的IgG及IgM水平比较,差异无统计学意义(P>0.05);轻、中、重度HIE患儿CD19~+、CD19~+CD25~+、IgA、IgM、补体C3及C4水平比较,差异均有统计学意义(均P<0.01),且HIE患儿的免疫功能随着病情的加重而衰减。结论与正常健康新生儿相比,HIE患儿的体液免疫功能明显受抑制,且HIE患儿的病情越严重,其受抑制的状态就越明显。
OBJECTIVE: To investigate the effects of immunophenotyping (CD19 ~ +, CD19 ~ + CD25 ~ +) and five immunoglobulin (IgA, IgG, IgM and complement C3 and C4) on the pathogenesis of neonatal hypoxic-ischemic encephalopathy In order to provide some theoretical basis for the prevention and treatment of children with HIE. Methods The clinical data of 72 HIE children (HIE group) who were treated in this hospital from February 2015 to April 2017 were analyzed. In addition, 70 newborn infants (control group) born in normal full-term obstetric department during the same period were selected. Baseline data, B lymphocyte phenotypes and immune expression of the two groups were compared. Compared with mild, moderate and severe HIE children B lymphocyte phenotype and immune expression of five. Results There was no significant difference in gender, gestational age, and age between the two groups (all P> 0.05). The levels of CD19 ~ +, CD19 ~ + CD25 ~ +, IgA, (P <0.01). There was no significant difference in IgG and IgM levels between two groups (P> 0.05). The levels of CD19 ~ +, CD19 ~ + CD25 ~ +, IgA, IgM, complement C3 and C4 levels were significantly different (all P <0.01), and the immune function of HIE patients decayed with the severity of the disease. Conclusion Compared with normal healthy newborns, the humoral immune function of HIE children is obviously inhibited. The more severe the HIE infants, the more inhibited the HIE infants.