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目的探讨对原发性高血压合并糖耐量异常(IGT)患者进行高血糖干预治疗的转归。方法筛选原发性高血压合并IGT患者(45～80岁)121人,分两组(干预组,对照组),两组均给予降压及调脂等治疗以及生活方式指导,干预组同时给予二甲双胍治疗餐后高血糖,随访2年。结果2年后干预组无一例发展为糖尿病,对照组13例(21.7%)进展为糖尿病。对照组心衰及脑卒中的发病率均高于干预组。结论原发性高血压合并IGT的患者在降压调脂等综合治疗基础上早期干预餐后高血糖,可显著减少新发糖尿病的发生率,降低心脑血管事件的发生率,提示重视筛查IGT及早期干预的重要性。
Objective To investigate the outcomes of hyperglycemic intervention in patients with essential hypertension complicated with impaired glucose tolerance (IGT). Methods 121 patients with essential hypertension (45-80 years old) were selected and divided into two groups (intervention group and control group). Both groups were given antihypertensive and lipid-lowering therapy and lifestyle guidance. The patients in intervention group were given concurrent treatment Metformin treatment of postprandial hyperglycemia, followed up for 2 years. Results After 2 years, none of the intervention group developed diabetes, and 13 cases (21.7%) of the control group progressed to diabetes. The incidence of heart failure and stroke in the control group were higher than those in the intervention group. Conclusions The early intervention of postprandial hyperglycemia in patients with essential hypertension complicated with IGT can significantly reduce the incidence of new onset diabetes mellitus and reduce the incidence of cardiovascular and cerebrovascular events, The importance of IGT and early intervention.