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【目的】探讨姜黄素作用不同时间和剂量对胃肠蠕动的影响,寻找姜黄素作用的最佳时间和剂量。【方法】昆明种小鼠,随机分组,每组8只。姜黄素[200mg/(kg.d)]预先灌胃分为1、5、10d和15d组;姜黄素灌胃10d,每公斤体重100、200、300、400mg组。采用阿托品腹腔注射减弱胃肠运动模型,用墨汁灌胃法分别测量各组小鼠胃残留率和小肠推进率。【结果】阿托品导致小鼠胃残留率增加,小肠推进率显著下降。姜黄素灌胃1和5d组,小鼠胃残留率和小肠推进率与阿托品组比均无明显变化,而姜黄素灌胃10和15d组,小鼠胃残留率显著下降,小肠推进率明显提高(P<0.01),10d和15d组间差异无统计学意义。100～400mg/kg姜黄素灌胃10d,对阿托品小鼠胃残留率和小肠推进率均有显著改善,各组间无明显差异。【结论】姜黄素100mg/(kg.d)、灌胃10d可以显著提高阿托品减弱的小鼠胃肠动力。
【Objective】 To investigate the effects of curcumin on gastrointestinal motility at different times and doses, and find out the optimal time and dosage of curcumin. 【Method】 Kunming mice were randomly divided into 8 groups. Curcumin [200mg / (kg.d)] was pre-gavage divided into 1, 5, 10d and 15d groups; curcumin gavage 10d, 100,200,300,400 mg per kg body weight. Intraperitoneal injection of atropine attenuated the gastrointestinal motility model, and the gastric residual rate and small intestine propulsion rate were measured by ink gavage method. 【Results】 Atropine caused increased gastric residual rate in mice and decreased intestinal propulsion rate. Curcumin gavage 1 and 5d group, gastric residual rate and small intestine propulsion rate and atropine group had no significant change, while 10 and 15d group curcumin gavage mice gastric residual rate decreased significantly, small intestine propulsion rate was significantly increased (P <0.01). There was no significant difference between 10d and 15d groups. 100 ~ 400mg / kg curcumin for 10 days, atropine mice gastric residual rate and intestinal propulsion rate were significantly improved, no significant difference between the groups. 【Conclusion】 Curcumin 100mg / (kg.d), gavage 10d can significantly improve gastrointestinal motility in mice with atropine decreased.