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目的:分析总结T-幼淋细胞白血病的临床特点、诊断及治疗现状。方法:回顾性分析1例T-幼淋细胞白血病患者临床资料并复习相关文献。结果:骨髓穿刺可见幼淋细胞,流式细胞学分析示CD2+CD3+CD5+CD7+CD8+CD4-TdT-HLA-DR-CD1a-CD19-。染色体:46,XX,inv(14)(q11;q32)。给予化疗,化疗第10天突发低血容量性休克自动出院。结论:T-幼淋细胞白血病是一种少见的胸腺后淋巴细胞增殖性疾病,侵袭性高,中位生存期短。多种新药的临床应用及异基因干细胞移植为该病提供了治疗前景。
Objective: To summarize the clinical features, diagnosis and treatment of T-lymphoblastic leukemia. Methods: A retrospective analysis of 1 case of T-lymphoblastic leukemia in patients with clinical data and review of relevant literature. Results: Bone marrow cells were observed in juvenile lymphocytes. Flow cytometry analysis showed CD2 + CD3 + CD5 + CD7 + CD8 + CD4-TdT-HLA-DR-CD1a-CD19-. Chromosomes: 46, XX, inv (14) (q11; q32). Given chemotherapy, chemotherapy, hypovolemic shock on the 10th day of spontaneous discharge. Conclusion: T-lymphocytic leukemia is a rare thymus lymphoproliferative disease with high invasiveness and short median survival. The clinical application of a variety of new drugs and allogeneic stem cell transplantation provide a therapeutic perspective for the disease.