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目的 :探讨方剂配伍对吸收入体内血药浓度及其药物动力学参数的影响。方法 :用已建立的 HPL C法 [1 ] ,测定健康自愿者一次口服川芎汤 (1g· kg- 1 )、冠心 号汤 (6 g/kg,其中川芎为 1g/kg)后血清中阿魏酸 (FA)的血药浓度 -时间曲线。结果 :均表现为双峰现象 ;川芎汤和冠心 号在健康人血清中 FA的血药浓度时间曲线下面积(AU C)分别为 15 735± 70 6 4和 15 886± 80 6 2 μg· L- 1· m in- 1 ;健康人血清中川芎复方来源的 FA血药浓度最高和最低定量值之间表现出 3～ 8倍的差异。结论 :在冠心 号中川芎配伍芍药、红花和丹参等并不影响体内 FA的血药浓度及其生物利用度。
Objective : To explore the effects of prescription compatibility on plasma concentration and its pharmacokinetic parameters absorbed into the body. METHODS: Using the established HPL C method [1], the serum of healthy volunteers was administered once after oral administration of Chuanxiong Decoction (1g·kg-1) and Guanxinhao Decoction (6 g/kg, of which Chuanxiong was 1g/kg). The plasma concentration-time curve of ferulic acid (FA). RESULTS: All showed a double peak phenomenon; the area under the blood concentration time curve of FA in healthy human serum (AU C) was 15 735 ± 70 6 4 and 15 886 ± 80 6 2 g, respectively. L- 1 · m in- 1 ; Serum concentrations of FA in traditional Chinese medicines from healthy people showed a difference of 3-8 times between the highest and lowest values of FA plasma concentrations. Conclusion : The Chuanxin No. Chuanxiong combined with peony, safflower and Salvia miltiorrhiza etc. does not affect the plasma concentration and bioavailability of FA in vivo.