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目的:观察芬太尼透皮贴剂对食管癌患者术后疼痛的镇痛效果。方法:选取2015年1月至2016年1月期间在我院行手术治疗的食管癌患者100例,采取国际通用随机字母表法将入组患者分为两组,观察组和对照组均包含50例。观察组患者在手术治疗后6h给予芬太尼透皮缓释贴剂进行镇痛,对照组患者给予自控静脉给药进行镇痛。结果:观察组和对照组患者术后6h、12h、24h、48h及72h时的VAS评分相当,比较差异不具有显著性(P>0.05)。观察组和对照组患者术后排痰效果分别为(2.04+0.78)分和(1.94+0.71)分,组间差异不具有显著性(P>0.05)。观察组和对照组患者术后3d发生呼吸抑制的例数分别为5例和3例,组间差异不具有显著性(P>0.05)。观察组和对照组患者术后出现恶心呕吐的例数分别为5例和4例,组间差异不具有显著性(P>0.05)。结论:芬太尼透皮贴剂能够取得与自控静脉给药方式相当的镇痛效果和临床应用安全性,但是与自控静脉给药相比,芬太尼透皮贴剂具有使用方便、无创伤,不影响患者活动的临床优势,值得在临床上进行推广应用。
Objective: To observe the analgesic effect of fentanyl transdermal patch on postoperative pain in patients with esophageal cancer. Methods: A total of 100 patients with esophageal cancer undergoing surgery in our hospital from January 2015 to January 2016 were enrolled. Patients were divided into two groups according to the international random alphabet method. The observation group and the control group included 50 example. Patients in the observation group were given analgesia with transdermal delivery of fentanyl 6 hours after surgery, and patients in the control group were given intravenous drugs for analgesia. Results: The VAS scores of observation group and control group at 6h, 12h, 24h, 48h and 72h after operation were similar, but the difference was not significant (P> 0.05). The postoperative sputum output in observation group and control group were (2.04 + 0.78) points and (1.94 + 0.71) points, respectively. There was no significant difference between the two groups (P> 0.05). The number of respiratory depression cases in observation group and control group were 5 and 3 cases after operation, respectively. There was no significant difference between the two groups (P> 0.05). The number of patients with nausea and vomiting in the observation group and the control group were 5 and 4, respectively. There was no significant difference between the two groups (P> 0.05). CONCLUSIONS: Fentanyl transdermal patches are comparable in analgesic efficacy and clinical safety with controlled intravenous administration, but fentanyl transdermal patches are easy to use and non-invasive compared to controlled intravenous , Does not affect the clinical advantages of patient activity, it is worth to promote the clinical application.