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目的:探讨人乳头瘤病毒(HPV)感染及其负荷量与宫颈病变发生、发展的相关性。方法:对894例普查妇女进行宫颈液基薄层细胞学检查(TCT)及高危型HPV-DNA检测,其中394例宫颈病变患者继续进行阴道镜评估和活检,比较不同宫颈病变组HPV感染情况。结果:各实验组高危型HPV-DNA的阳性率比较差异有统计学意义(P<0.05)。各组HPV-DNA负荷量比较,正常组与炎症组、CINⅠ组与CINⅡ组差异无统计学意义。TCT与HPV对宫颈病变检出率差异有统计学意义(P<0.01)。与病理结果比较,TCT诊断为炎症、低度鳞状上皮内病变(LSIL)、高度鳞状上皮内病变(HSIL)及宫颈癌的符合率分别为94.1%、76.3%、75.0%和71.4%。结论:随着病变级别的增加,HPV感染阳性率逐渐上升。HPV-DNA的负荷量并不完全随宫颈病变的加重而逐级递增。
Objective: To investigate the relationship between human papillomavirus (HPV) infection and its load and the occurrence and development of cervical lesions. Methods: A total of 894 women underwent cervical cytology (TCT) and high-risk HPV-DNA test. 394 cervical lesions were evaluated by colposcopy and biopsy. HPV infection in different cervical lesions was compared. Results: The positive rate of high-risk HPV-DNA in each experimental group was significantly different (P <0.05). The load of HPV-DNA in each group was no significant difference between normal group and inflammation group, CINⅠgroup and CINⅡgroup. The detection rate of cervical lesions by TCT and HPV was significantly different (P <0.01). Compared with pathological results, the coincidence rates of TCT diagnosis of inflammation, low grade squamous intraepithelial lesion (LSIL), high grade squamous intraepithelial lesion (HSIL) and cervical cancer were 94.1%, 76.3%, 75.0% and 71.4%, respectively. Conclusion: The positive rate of HPV infection gradually increases with the increase of the grade of lesions. The load of HPV-DNA does not completely increase gradually with the increase of cervical lesions.