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目的 :探讨周围型非小细胞肺癌 (NSCLC)的CT征像与 p2 1蛋白表达的相关性。 方法 :对 72例经手术病理证实的周围型NSCLC术前进行CT扫描 ,并用SP法对肿瘤标本 p2 1蛋白进行免疫组化染色。 结果 :⑴CT显示肿瘤的直径 >3cm及有深分叶征、棘状突起、纵隔淋巴结肿大者p2 1蛋白表达升高。⑵肺癌的 p2 1蛋白表达与肿瘤分化程度及组织学类型有关。结论 :周围型NSCLC的CT征像中肿瘤的直径 >3cm ,深分叶征、棘状突起及纵隔淋巴结转移与 p2 1蛋白表达密切相关 ,具有相对更高的恶性程度 ,可作为推测预后的指标
Objective: To investigate the correlation between CT signs and p21 protein expression in peripheral non-small cell lung cancer (NSCLC). Methods : CT scanning was performed on 72 cases of peripheral NSCLC confirmed by pathology. Immunohistochemical staining of p21 protein in tumor specimens was performed by SP method. Results: (1) CT showed that the diameter of tumor was >3cm and the expression of p21 protein was increased in patients with deep lobular sign, spinous process and mediastinal lymphadenopathy. (2) The expression of p21 protein in lung cancer is related to tumor differentiation and histological type. Conclusion :The tumor diameter of peripheral NSCLC is more than 3cm in diameter. The deep leaf marking, spinous process and mediastinal lymph node metastasis are closely related to the expression of p21 protein. It has a relatively higher degree of malignancy and can be used as a predictor of prognosis.