阿霉素每周给药与3周给药的疗效及毒副反应比较

• 作 者: 段庚仙 王小平 侯淑玲 李雯谨 张俊萍 郭秀英
• 机 构: 山西省肿瘤医院，晋中地区第一人民医院
• 出 处: 肿瘤研究与临床
• 发表日期: 1995年02期
• 关键词: 周给 累积剂量 小细胞肺癌 白细胞降低 大者 联合化疗 垂直径 鳞癌 广谱抗癌 初治病例

１９９４年３月～１９９４年１１月对阿霉素每周给药与３周给药的疗效与毒性进行观察，从疗效看两组相近，从毒副反应看，心脏毒性两组无明显差异，这与阿霉毒累积剂量低有关，故分次应用阿霉毒应选择阿霉素累积剂量大者，因累积剂量越大毒性也增大。消化道反应以３周给药组为重，而血液系统毒性白细胞降低以每周给药组明显有关原因有待进一步研究。

From March 1994 to November 1994, the efficacy and toxicity of weekly doxorubicin and three weeks of administration were observed. From the perspective of efficacy, the two groups were similar. From the toxic side effects, there was no significant difference between the two groups in cardiotoxicity. This is related to the low cumulative dose of alphamycin. Therefore, the cumulative dose of doxorubicin should be selected for multiple applications of amyloid, and the cumulative toxicity increases as the cumulative dose increases. Gastrointestinal reaction was emphasized in the 3-week administration group, and the decrease in hematologic toxicity of leukocytes was evident in the weekly administration group for further investigation.