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目的:对糖尿病肾病血液透析患者应用阿司匹林预防内瘘血栓形成的疗效进行分析。方法:28例糖尿病肾病血液透析患者随机分为2组,两组均使用诺和胰岛素管理血糖,以动静脉内瘘为血管通路,治疗组15例,对照组13例,治疗组每日口服阿司匹林100 mg。通过动静脉内瘘多普勒及临床观察,评价阿司匹林对预防糖尿病肾病患者内瘘血栓形成的疗效及其副作用。结果:治疗1年后,治疗组的内瘘通畅率和对照组相当,两组动静脉内瘘血流量均有下降但治疗组下降较为缓慢,其差异有统计学意义(P<0.05)。结论:阿司匹林在预防糖尿病肾病动静脉内瘘血栓形成中有一定疗效。
Objective: To analyze the efficacy of aspirin in prevention of fistula thrombosis in hemodialysis patients with diabetic nephropathy. Methods: 28 hemodialysis patients with diabetic nephropathy were randomly divided into 2 groups. Novo-insulin was used to manage blood glucose in both groups. Arterio-venous fistula was used as vascular access. 15 patients in the treatment group and 13 in the control group were treated with aspirin 100 mg. Through the arteriovenous fistula Doppler and clinical observation, evaluation of aspirin in the prevention of diabetic nephropathy fistula thrombosis efficacy and side effects. Results: After 1 year of treatment, the rate of fistula patency in the treatment group was similar to that in the control group. The blood flow of the arteriovenous fistula in both groups decreased but the treatment group decreased slowly. The difference was statistically significant (P <0.05). Conclusion: Aspirin has certain curative effect in preventing arteriovenous fistula thrombosis of diabetic nephropathy.