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目的探讨新生儿化脓性脑膜炎的实验室指标特征,为临床诊治提供依据。方法对39例新生儿化脓性脑膜炎的血液及脑脊液等相关实验室指标进行综合分析。结果 (1)血液指标:治疗前血常规白细胞总数、中性粒细胞比例、CRP均高于治疗后,治疗前后比较均有显著差异。治疗前后血小板比较无显著差异。部分患儿可发生低钠血症(5.2%),ALT增高5例(12.8%),血培养阳性率不高(12.8%)。(2)脑脊液指标:脑脊液白细胞数,蛋白含量是化脓性脑膜炎恢复的敏感指标。氯化物随病情好转渐增高,但不敏感。糖恢复较慢,不宜作为化脓性脑膜炎恢复指标。脑脊液细菌培养阳性率低。结论新生儿化脓性脑膜炎的血及脑脊液变化有其规律,研究此病实验室指标变化规律,可进一步指导临床诊治。
Objective To investigate the characteristics of neonatal purulent meningitis laboratory indicators for clinical diagnosis and treatment provide the basis. Methods A total of 39 neonatal purulent meningitis blood and cerebrospinal fluid and other related laboratory indicators were analyzed. Results (1) Blood index: Before treatment, the total leukocyte count, neutrophil ratio and CRP were all higher than those before treatment, before and after treatment, there were significant differences. There was no significant difference in platelet before and after treatment. Some children may develop hyponatremia (5.2%), ALT increased in 5 cases (12.8%), blood culture positive rate is not high (12.8%). (2) indicators of cerebrospinal fluid: cerebrospinal fluid leukocytes, protein content is a sensitive indicator of purulent meningitis recovery. Chloride gradually improved with the condition improved, but not sensitive. Sugar recovery is slow, not as purulent meningitis recovery indicators. The positive rate of cerebrospinal fluid bacterial culture is low. Conclusions Neonatal purulent meningitis has its own rules of blood and cerebrospinal fluid changes. The change of laboratory indexes in this disease can be further guided clinical diagnosis and treatment.