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目的检测妊娠期糖尿病(gestational diabetes mellitus,GDM)患者中巨细胞病毒感染的发生率,探讨妊娠期糖尿病合并巨细胞病毒感染对妊娠妇女凝血功能的影响。方法妊娠期糖尿病患者158例作为试验组,136例健康孕妇作为对照组,检测人巨细胞病毒(human cytomegalovirus,HCMV)阳性感染率,根据是否感染,将以上两组又分为HCMV阳性组和阴性组。检测凝血酶原时间(prothrombin time,PT)、活化部分凝血活酶时间(activated partialthromboplastin time,APTT)以及纤维蛋白原(fibrinogen,Fib)变化,分析血糖升高和病毒感染对凝血功能的影响。结果妊娠期糖尿病患者HCMV阳性感染率29.11%,高于对照组7.35%,差异具有统计学意义(P<0.01)。单纯HCMV阳性感染健康孕妇组与阴性对照组比较,PT、APTT缩短,Fib升高,GDM合并HCMV感染与单纯血糖升高患者比较,PT、APTT缩短,差异有统计学意义(P<0.01)。结论妊娠期糖尿病妇女容易诱发HCMV感染,GDM孕妇合并HCMV感染可加重患者高凝血状态,存在血栓形成倾向。
Objective To detect the incidence of cytomegalovirus infection in gestational diabetes mellitus (GDM) and to investigate the influence of gestational diabetes mellitus (CMV) infection on the coagulation function in pregnant women. Methods A total of 158 pregnant women with gestational diabetes mellitus (DM) as experimental group and 136 healthy pregnant women as control group were enrolled in this study. The positive rate of human cytomegalovirus (HCMV) infection was detected. According to whether infected or not, the above two groups were divided into HCMV positive group and negative group group. The changes of prothrombin time (PT), activated partial thromboplastin time (APTT) and fibrinogen (Fib) were detected. The influence of hyperglycemia and viral infection on coagulation function was analyzed. Results The positive rate of HCMV infection in gestational diabetes mellitus was 29.11%, which was higher than that in control group (7.35%), the difference was statistically significant (P <0.01). Compared with the negative control group, the HCT-positive and HCMV-infected pregnant women had shorter PT and APTT, higher Fib, and shorter PT and APTT compared with those with pure HCMV infection and simple hyperglycemia. The difference was statistically significant (P <0.01). Conclusions Pregnant women with diabetes mellitus are susceptible to HCMV infection. HCMV infection in pregnant women with GDM may aggravate the hypercoagulable state of patients with thrombophilia.