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具有急性转化作用的逆转录病毒野生型逆转录病毒仅有微弱的转化作用,它们通过特有的基因gag,env和pol编码相应的蛋白质。具有急性转化作用的逆转录病毒从细胞中获得了额外的基因或其一部分,即癌基因,后者的突变或异常的表达即导致细胞转化。众所周知,有些癌基因编码蛋白激酶,然而,这并非转化基因的一个基本特征,因为,ras、myc和sis病毒癌基因编码的是其它类型的转化蛋白质。癌基因编码的蛋白激酶彼此间相差甚远,例如,
Retroviral wild-type retroviruses with acute transformation have only a weak transformation, and they encode the corresponding proteins through the unique genes gag, env and pol. Retroviruses with acute transformation obtain additional genes or portions thereof from the cells, ie, oncogenes, and the latter mutation or aberrant expression results in cellular transformation. It is well known that some oncogenes encode protein kinases, however, this is not an essential feature of the transformed gene because the ras, myc and sis viral oncogenes encode other types of transformed proteins. Oncogene-encoded protein kinases are far from each other, for example,