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目的研究分析放射治疗联合康莱特治疗中老年鼻咽癌患者的疗效和不良反应。方法 126例中老年鼻咽癌患者随机分为治疗组63例(放射治疗联合康莱特)和对照组(单纯放射治疗)63例,治疗组除放射治疗外,每天缓慢静脉滴注康莱特注射液1次,21天为1个疗程,间隔3~5天。比较两组的近期疗效、1、3年生存率及不良反应。结果治疗组近期疗效有效率为96.83%(61/63),对照组有效率为76.19%(48/63),两组差异有统计学意义(P<0.05)。远期疗效治疗组1、3年生存率为93.65%和88.89%,对照组1、3年生存率为71.43%和63.49%,差异有统计学意义(P<0.05)。不良反应治疗组患者的发生率为20.63%,对照组患者的发生率为36.51%,差异有统计学意义(P<0.05)。结论放射治疗联合康莱特能提高中老年鼻咽癌患者的近期疗效、减轻不良反应且能提高1、3年生存率,是治疗中老年鼻咽癌的一种行之有效的治疗方法。
Objective To study the efficacy and adverse reactions of radiotherapy combined with Kanglaite in the treatment of middle-aged and elderly patients with nasopharyngeal carcinoma. Methods 126 cases of middle-aged and elderly patients with nasopharyngeal carcinoma were randomly divided into treatment group 63 cases (radiotherapy combined with KLT) and control group (radiotherapy alone) 63 cases, the treatment group in addition to radiation therapy, daily slow intravenous infusion of KLT 1 times, 21 days for a course of treatment, an interval of 3 to 5 days. The two groups were compared the short-term efficacy, 1, 3-year survival rate and adverse reactions. Results The effective rate of the treatment group was 96.83% (61/63), while that of the control group was 76.19% (48/63). The difference between the two groups was statistically significant (P <0.05). The 1-year and 3-year survival rates of long-term curative effect group were 93.65% and 88.89%, respectively. The 1-year and 3-year survival rates of the control group were 71.43% and 63.49%, respectively. The difference was statistically significant (P <0.05). The incidence of adverse reactions in treatment group was 20.63%, while that in control group was 36.51%, the difference was statistically significant (P <0.05). Conclusion Radiation combined with Kanglaite can improve the short-term effect of nasopharyngeal carcinoma in middle-aged and elderly patients, reduce the adverse reaction and improve the one and three year survival rate. It is an effective treatment for middle-aged and elderly patients with nasopharyngeal carcinoma.