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应用北京医科大学微生物学系研制的抗HEV诊断试剂检测171例各型肝炎病人及46例健康人血清,并与新加坡DBL公司生产的抗HEV诊断试剂进行比较。两种试剂检测的总符合率为96.64%。在各型肝炎病人中抗HEV的检出率为94.92%,健康人中未见阳性反应。对22例戊型肝炎病人进行一年的追踪观察,阳性检出率仍为68.18%,但抗HEV效价呈现下降趋势。结果显示了病人感染HEV后抗HEV出现的较早,维持时间较长,对急性戊型肝炎的诊断有必要观察血清抗HEV的动态变化。
The anti-HEV diagnostic reagent developed by Department of Microbiology, Beijing Medical University was used to detect the serum of 171 patients with hepatitis B and 46 healthy people, and compared with the anti-HEV diagnostic reagent produced by Singapore DBL Company. The total coincidence rate of the two reagents was 96.64%. In all types of hepatitis patients anti-HEV detection rate was 94.92%, no positive reaction in healthy people. A follow-up observation of 22 cases of hepatitis E patients for one year showed that the positive detection rate was still 68.18%, but the anti-HEV titer showed a downward trend. The results showed that the anti-HEV appeared earlier and sustained longer after the patient was infected with HEV. It is necessary to observe the dynamic changes of serum anti-HEV in the diagnosis of acute hepatitis E.