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[目的]探讨胃癌术前动脉插管化疗的疗效。[方法]对24例进展期胃癌术前进行1~2次动脉插管化疗,一次灌注大剂量抗癌药,化疗后观察;临床症状、肿块大小变化,术后对切除标本进行病理分析。[结果]化疗后临床症状减轻,全身症状改善,毒副作用小,并能使肿块缩小,提高手术切除率,减少术中肝转移、医源性扩散和术后复发。术后病理检查有20例出现不同程度的化疗反应,有效率83.3%。[结论]术前插管化疗对胃癌有较好疗效,有效率与插管部位、插管次数、药物剂量及分化程度有关。
[Objective] To explore the curative effect of preoperative arterial intubation chemotherapy for gastric cancer. [Methods] Twenty-four patients with advanced gastric cancer were treated with arterial intubation 1 to 2 times before operation, once infusion of large-dose anticancer drugs, and observed after chemotherapy. Clinical symptoms and changes in tumor size were analyzed. Pathological analysis was performed on the resected specimens. [Results] After chemotherapy, the clinical symptoms were relieved, the systemic symptoms were improved, the toxic and side effects were small, and the tumors could be reduced, the surgical resection rate was improved, and the intraoperative liver metastasis, iatrogenic diffusion, and postoperative recurrence were reduced. Postoperative pathological examination showed 20 cases of different degrees of chemotherapy response with an effective rate of 83.3%. [Conclusion] Preoperative intubation chemotherapy has good curative effect on gastric cancer, and the effective rate is related to the location of intubation, the number of intubations, drug dosage and differentiation degree.