论文部分内容阅读
目的评价希罗达联合周剂量奥沙利铂治疗老年晚期胃癌的近期疗效及毒副反应。方法初治组12例,复治组8例。患者给予希罗达1000 mg/m2,饭后半小时口服,2次/d,第1～14天;静脉滴注奥沙利铂65 mg/m2,每周1次,连用2周,每3周重复。2个周期化疗后进行疗效和不良反应评估。结果全组20例,治疗总有效率为45.0%。初治组有效率为50%,复治组有效率为37.5%。主要不良反应为Ⅰ、Ⅱ度白细胞下降和消化道反应;少数患者出现Ⅰ～Ⅱ度周围神经毒性。结论希罗达联合周剂量奥沙利铂治疗老年晚期胃癌疗效显著,耐受性良好。
Objective To evaluate the efficacy and toxicity of Xeloda combined with weekly oxaliplatin in the treatment of elderly patients with advanced gastric cancer. Methods The initial treatment group of 12 cases, retreatment group of 8 cases. Patients were given Xeloda 1000 mg / m2, orally for half an hour after meal, 2 times / d, days 1 to 14; intravenous oxaliplatin 65 mg / m2, once a week for 2 weeks, every 3 Weeks repeated. Efficacy and adverse effects assessment after 2 cycles of chemotherapy. Results The whole group of 20 cases, the total effective rate was 45.0%. The effective rate of initial treatment group was 50% and that of retreatment group was 37.5%. The main adverse reactions were grade Ⅰ and Ⅱ leukopenia and gastrointestinal reactions; a few patients showed grade Ⅰ ~ Ⅱ peripheral neurotoxicity. Conclusion Xeloda combined with weekly dosage of oxaliplatin in the treatment of advanced gastric cancer has obvious curative effect and good tolerance.