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目的:评估分别以质子泵抑制剂(PPI),铋剂(CBS),H.受体拮抗剂(H_2RA)为基础的一周三联疗法对幽门螺杆菌(Helicobakter pyloriHP)的根除率。方法:65例中HP(+)患者随机分为三组,均给予一周三联根除HP治疗。A组为 PPI20mg+阿莫西林 1.0g+甲硝唑0.4g 均 Bid,B组为 CBS120mg+克拉霉素 0.25g+甲硝唑0.4g均Bid,C组为H_2RA(泰胃美或法莫替丁20mg,雷尼替丁150mg)Bid+阿莫西林1.0+甲硝唑0.4g均Bid。停药至少4周后复查~(14)C—UBT。结果:A 组根除率为85.7％(18/21);B组为87.5％(21/14);C组为80％(16/20)。结论:以PPI为基础及含克拉霉素的以铋剂为基础的一周三联方案可获得相似的根除率但根除率并未达到90％。
OBJECTIVE: To evaluate the eradication rate of Helicobactor pylori (HP) by one week triple therapy based on proton pump inhibitor (PPI), bismuth (CBS) and H. Receptor antagonist (H 2 RA) respectively. Methods: 65 cases of HP (+) patients were randomly divided into three groups were given a week of triple therapy eradicate HP. Bid group A was PPI20mg + amoxicillin 1.0g + metronidazole 0.4g, Bid B was CBS120mg + clarithromycin 0.25g + metronidazole 0.4g, group C was H_2RA (TSTE or famotidine 20mg, Nimidine 150mg) Bid + amoxicillin 1.0 + metronidazole 0.4g Bid. Re-examination after discontinuation of at least 4 weeks ~ (14) C-UBT. Results: The eradication rate was 85.7% (18/21) in group A, 87.5% (21/14) in group B, and 80% (16/20) in group C. CONCLUSIONS: A three-week program based on PPI and containing clarithromycin based on bismuth achieved similar eradication rates but the eradication rate did not reach 90%.